Imaging and Defining Emergent Behaviors of the Immune Response

2023

Hu KH, Kuhn NF, Courau T, Tsui J, Samad B, Ha P, Kratz JR, Combes AJ, Krummel MF. Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer. Cell Stem Cell. 2023 Jun 1;30(6):885-903.e10. . PMID: 37267918 [PDF]

Combes AJ, Samad B, Krummel MF. Defining and using immune archetypes to classify and treat cancer. Nat Rev Cancer. 2023 Jun 5. doi: 10.1038/s41568-023-00578-2. PMID: 37277485 [PDF]

Beppler C, Eichorst J, Marchuk K, Cai E, Castellanos CA, Sriram V, Roybal KT, Krummel MF. Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors. J Cell Biol. 2023 Mar 6;222(3):e202205118.  Dec 15. PMID: 36520493 [PDF]

Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung. Cell Rep. 2023 May 30;42(6):112582.   PMID: 37261951[PDF]

Munson PV, Adamik J, Hartmann FJ, Favaro PMB, Ho D, Bendall SC, Combes AJ, Krummel MF, Zhang K, Kelley RK, Butterfield LH. Polyunsaturated Fatty Acid-Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism. Cancer Res. 2023 May 2;83(9):1543-1557. PMID: 3684761 [PDF]

Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, Huang EJ. Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. J Clin Invest. 2023 Mar 15;133(6):e164919. . PMID: 36602862 [PDF]

Rahim MK, Okholm TLH, Jones KB, McCarthy EE, Liu CC, Yee JL, Tamaki SJ, Marquez DM, Tenvooren I, Wai K, Cheung A, Davidson BR, Johri V, Samad B, O'Gorman WE, Krummel MF, van Zante A, Combes AJ, Angelo M, Fong L, Algazi AP, Ha P, Spitzer MH. Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes. Cell. 2023 Mar 16;186(6):1127-1143.e18..PMID: 36931243 [PDF]

2022

Cai E,Beppler C, Eichorst J, Marchuk K, Eastman SW, Krummel MF.  T cells use distinct topographical and membrane receptor scanning strategies that individually coalesce during receptor recognition. PNAS 2022 119(32):e22032471192. PMID: 35914144 [PDF]

You R, Artichoker J, Ray A, Gonzalez Velozo H, Rock DA, Conner KP, Krummel MF Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy. Cancer Immunol Res. 2022 10(6):698-712. PMID: 35413104 [PDF]

Laviron, M, Petit, M, Weber-Delacroix, E, Combes, AJ, Arkal, AR, Barthélémy, S, Courau, T,  Hume, DA, Combadière, C, Krummel, MF, Boissonnas A.  Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. 2022. Cell reports 39, 110865 [PDF]

Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A; UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH. Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients. Immunity. 2022 S1074-7613(22)00242-4. PMID: 35779527 [PDF]

Kersten K, Hu KH, Combes AJ, Samad B, Harwin T, Ray A, Rao AA, Cai E, Marchuk K, Artichoker J, Courau T, Shi Q, Belk J, Satpathy AT, Krummel MF Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer. Cancer Cell. 2022 40(6): 624-638. PMID: 35623342 [PDF]

Mujal AM, Combes AJ, Rao AA, Binnewies M, Samad B, Tsui J, Boissonnas A, Pollack JL, Argüello RJ, Meng MV, Porten SP, Ruhland MK, Barry KC, Chan V, Krummel MF.Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer. Cancer Immunol Res. 2022 Apr 1;10(4):403-419. doi: 10.1158/2326-6066.CIR-21-0588. PMID: 35181780[PDF]

Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB; Immunoprofiler Consortium, Cai C, Zhan J, Davis KC, Kelley RK, Chapman JS, Atreya CE, Patel A, Daud AI, Ha P, Diaz AA, Kratz JR, Collisson EA, Fragiadakis GK, Erle DJ, Boissonnas A, Asthana S, Chan V, Krummel MF. Discovering dominant tumor immune archetypes in a pan-cancer census. Cell. 2022 Jan 6;185(1):184-203.e19. doi: 10.1016/j.cell.2021.12.004. Epub 2021 Dec 27. PMID: 34963056. [PDF]

Kratz JR, Li JZ, Tsui J, Lee JC, Ding VW, Rao AA, Mann MJ, Chan V, Combes AJ, Krummel MF, Jablons DM. Genetic and immunologic features of recurrent stage I lung adenocarcinoma. Sci Rep. 2021 Dec 8;11(1):23690. doi: 10.1038/s41598-021-02946-0. PMID: 34880292; PMCID: PMC8654957.

Binnewies M, Pollack JL, Rudolph J, Dash S, Abushawish M, Lee T, Jahchan NS, Canaday P, Lu E, Norng M, Mankikar S, Liu VM, Du X, Chen A, Mehta R, Palmer R, Juric V, Liang L, Baker KP, Reyno L, Krummel MF, Streuli M, Sriram V. Targeting TREM2 on tumor-associated macrophages enhances immunotherapy. Cell Rep. 2021 Oct 19;37(3):109844. doi: 10.1016/j.celrep.2021.109844. PMID: 34686340. [PDF]

Jiang H, Courau T, Borison J, Ritchie AJ, Mayer AT, Krummel MF, Collisson EA. Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism. Gastroenterology. 2022 Feb;162(2):590-603.e14. doi: 10.1053/j.gastro.2021.09.066. Epub 2021 Oct 8. PMID: 34627860. [PDF]

2021

Im K, Combes AJ, Spitzer MH, Satpathy AT, Krummel MF. Archetypes of checkpoint-responsive immunity. Trends Immunol. 2021 Oct 9:S1471-4906(21)00183-6. doi: 10.1016/j.it.2021.09.007. PMID: 34642094. Review [PDF]

You R, Artichoker J, Fries A, Edwards A, Combes AJ, Reeder G, Samad B, Krummel MF. Active surveillance characterizes human intratumoral T cell exhaustion. J Clin Invest. 2021 Sep 15;131(18):e144353. doi: 10.1172/JCI144353. doi: 10.1172/JCI144353. PMID: 34292884. PMCID: PMC8439597 [PDF]

Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauster J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Rao AA, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtl T, Skurk C, Wolfgang P, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B. Increased risk of severe clinical course of COVID-19 incarriers of HLA-C*04:01. EClinicalMedicine. 2021 Sep 2:101099. doi: 10.1016/j.eclinm.2021.101099. PMID: 34490415. PMCID: PMC8410317. [PDF]

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 Sep1:ji2000970. doi: 10.4049/jimmunol.2000970. PMID 34470859

Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA; COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 Aug 26;12(1):5152. doi: 10.1038/s41467-021-25040-5. PMID: 34446707 [PDF]

van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ; UCSF COMET consortium. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci Transl Med. 2021 Aug 24:eabh2624. doi: 10.1126/svitranslmed.abh2624. PMID: 34429372. [PDF]

Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett PA, Marchuk K, Tran NT, Krummel MF, Stamou D, Weiner OD. The WAVE complex associates with sites of saddle membrane curvature. J Cell Biol. 2021 Aug 2;220(8):e202003086. doi: 10.1083/jcb.202003086. Epub 2021 Jun 7. PMID: 34096975. PMCID: PMC8185649. [PDF]

Cueto FJ, Del Fresno C, Brandi P, Combes AJ, Hernández-García E, Sánchez-Paulete AR, Enamorado M, Bromley CP, Gomez MJ, Conde-Garrosa R, Mañes S, Zelenay S, Melero I, Iborra S, Krummel MF, Sancho D. DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrat

Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL; COMET Consortium+, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. Impaired antibacterial immune signaling and changes in the lung microbiome precede seconday bacterial pneumonia in COVID-19. medRxiv. 2021 Mar 26:2021.03.23.21253487. doi: 10.1101/2021..03.23.21253487. PMID: 33791731. PMCID: PMC8010763. [PDF]

Pinkard H, Baghdassarian H, Mujal A, Roberts E, Hu KH, Friedman DH, Malenica I, Shagam T, Fries A, Corbin K, Krummel MF, Waller L. Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging. Nat Commun. 2021 Mar 26; 12(1):1916. doi: 10.1038/s41467-021-22246-5. PMID: 33772022 [PDF]

Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. A tumor-specific mechanism of T reg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 Mar 26;6(57):eabf0558. doi: 10.1126/sciimunol.abf0558. PMID: 33771888. [PDF]

Chan V, Gherardini PF, Krummel MF, Fragiadakis GK. A "data sharing trust" model for rapid, collaborative science. Cell. 2021 Feb 4;184(3):566-570. doi: 10.1016/j.cell.2021.01.006. PMID: 33545032. [PDF]

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui, J Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, WIlson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S; UCSF COMET Consortium, Matthay M, Erle DJ, Woodruf PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Jan 25. doi: 10.1038/s41586-021-03234-7. PMID: 33494096. [PDF]

2020

Argüello RJ, Combes AJ, Char R, Tabouret E, Gigan JP, Baaziz AI, Bousiquot E, Camosseto V, Samad B, Tsui J, Yan P, Bouissonneau S, Figarella-Branger D, Gatti E, Krummel MF, Pierre P.SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution. Cell Metabolism. 2020. Volume 32, Issue 6, Pages 1063-1075.e7. doi: 10.1016/j.cmet.2020.11.007. [PDF]

Freedman TS, Headley MB, Serwas N, Ruhland M, Castellanos CA, Combes AJ, Krummel MF. Lessons of COVID-19: A roadmap for post-pandemic science. J Exp Med. 2020 Sep 7;217(9):e20201276. doi: 10.1084/jem.20201276. PMID: 32735669. [PDF]

Bald T, Krummel MF, Smyth MJ, Barry KC. The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies. 2020 Jul 20. Nat Immunol. doi: 10.1038/s41590-020-0728-z. [PDF]

Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. 2020 Jul 6. Nat Methods. doi:10.1038/s41592-020-0880-2. [PDF]

Ruhland MK, Roberts EW, Cai E, Mujal AM, Marchuk K, Beppler C, Nam D, Serwas N, Binnewies M, Krummel MF. Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells. Cancer Cell. 2020 Jun 08. Volume 37, Issue 6, Pages 786-799.e5. doi: 10.1016/j.ccell.2020.05.002. [PDF]

Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI. Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma. Ann Surg Oncol. 2020 June 2. doi: 10.1245/s10434-020-08648-7. PMID: 32488521 [PDF]

Hu, K.H., Krummel, M.F. Carpet-bombing tumors with IFN-γ. Nat Cancer 1, 270–272. 2020 March. https://doi.org/10.1038/s43018-020-0042-6 [PDF]

Tang S, Cannon J, Yang K, Krummel MF, Baker JR Jr, Choi SK. Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine. J Org Chem. 2020 Mar 6;85(5):2945-2955. doi: 10.1021/acs.joc.9b02617. Epub 2020 Feb 5. PMID: 32020803. [PDF]

Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel MF, Pepper M, Rothlin CV, Wherry EJ, Once-a-Year Pledge Supporters. Reinvigorating NIH Grant Peer Review. Immunity 2020 Jan 14;52(1):1-3. doi: 10.1016/j.immuni.2019.12.016. PMID: 31940266. [PDF]

Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel MF, Narumiya S. mDia1/3-dependent Actin Polymerization Spatiotemporally Controls LAT Phosphorylation by Zap70 at Immune Synapse. Sci Adv. 2020 Jan 1;6(1):eaay2432. doi: 10.1126/sciadv.aay2432. eCollection 2020 Jan. PMID: 31911947. PMCID: PMC6938706. [PDF]

   

2019

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmdit TC, Rosenblum MD. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756. PMID: 31852848 [PDF]

Krummel MF, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M; Future Immunology Consortium. Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell. 2019 Dec 12;179(7):1441-1445. doi: 10.1016/j.cell.2019.11.029. PMID: 31835023. [PDF]

Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF, Sancho D. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2019 Aug 29. PMID: 31467405 [PDF]

Jahchan NS, Mujal AM, Pollack JL, Binnewies M, Sriram V, Reyno L, Krummel MF. Tuning the Tumor Myeloid Microenviornment to Fight Cancer. Front Immunol. 2019 Jul 25;10:1611. doi: 10.3389/fimmu.2019.01611. eCollection 2019. Review. PMID: 31402908. [PDF]

Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM. Pulmonary enviornmental cues drive gropu 2 innate lymphoid cell dynamics in mice and humans. Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638. PMID: 31175176 [PDF]

Mujal AM, Krummel MF. Immunity as a continuum of archetypes. Science. 2019 Apr 5;364(6435):28-29. [PDF]

Binnewies M, Mujal AM, Pollack JL, Combes AJ, Hardison EA, Barry KC, Tsui J, Ruhland MK, Kersten K, Abushawish MA, Spasic M, Giurintano JP, Chan V, Daud AI, Ha P, Ye CJ, Roberts EW, Krummel MF. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019 Apr 18;177(3):556-571.e16. doi: 10.1016/j.cell.2019.02.005. Epub 2019 Apr 4. [PDF]

Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 Mar 19;50(3):707-722.e6. [PDF]

Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ. α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas. J Immunother Cancer. 2019 Mar 4;7(1):62. doi: 10.1186/s40425-018-0493-9. [PDF]

Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.Mucosal Immunol. 2019 Jan;12(1):64-76. [PDF]

 

2018

Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 Nov 06; 115(45):11585-11590. PMID: 30348790. PMCID: PMC6233119 [PDF]

Krummel MF. Nobel notes value of basic research for new drugs. Nature. 2018 Nov;563(7730):184. doi: 10.1038/d41586-018-07307-y. No abstract available. PMID: 30405221. [PDF]

Barry K., Hsu J., Broz M., Cueto F., Binnewies M., Combes A., Nelson A., Loo K., Kumar R., Rosenblum M., Alvarado M., Wolf D., Bogunovic D., Bhardwaj N., Daud A., Ha P., Ryan W., Pollack J., Samad B., Asthana S., Chan V., Krummel M.F. A Natural Killer–Dendritic Cell Axis Defines Checkpoint Therapy–Responsive Tumor Microenvironments. Nature Medicine. 2018 June 25. doi: 10.1038/s41591-018-0085-8 [Epub ahead of print]. [PDF]

Bąbała N, Bovens A, de Vries E, Iglesias-Guimarais V, Ahrends T, Krummel MF, Borst J, Bins AD. Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin. Cancer Immunol Res. 2018 Jul;6(7):835-847. doi: 10.1158/2326-6066.CIR-17-0408. Epub 2018 May 15. PMID: 29764836 [PDF]

Binnewies M., Roberts E.W., Kersten K., Chan V., Fearon D.F., Merad M., Coussens L.M., Gabrilovich D.I., Ostrand-Rosenberg S., Hedrick C.C., Vonderheide R.H., Pittet M.J., Jain R.K., Zou W., Howcroft T.K., Woodhouse E.C., Weinberg R.A., Krummel M.F. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine. 2018 Apr 23. doi: 10.1038/s41591-018-0014-x [Epub ahead of print]. [PDF]

Hung L.Y., Oniskey T.K., Sen D, Krummel M.F., Vaughan A.E., Cohen N.A., Herbert D.R., Am J Pathol. Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.Am J Pathol. 2018 May;188(5):1161-1170. doi: 10.1016/j.ajpath.2018.01.020. Epub 2018 Feb 16. [PDF]

de Mingo Pulido Á., Gardner A, Hiebler S., Soliman H, Rugo H.S., Krummel M.F., Coussens LM, Ruffell B. TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer Cell. 2018 Jan 8;33(1):60-74.e6. doi: 10.1016/j.ccell.2017.11.019. [PDF]

 

2017

Loo, K., Tsai, K.K., Mahuron, K., Liu, J., Pauli, M.L., Sandoval, P.M., Nosrati, A., Lee, J., Chen, L., Hwang, J., Levine, L.S., Krummel, M.F., Algazi, A.P., Alvarado, M.D., Rosenblum, M.D., Daud, A.I. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 Jul 20;2(14). pii: 93433. doi: 10.1172/jci.insight.93433. [Epub ahead of print]. [PDF]

Yipp, B.G., Kim, J.H., Lima, R., Zbytnuik, L.D., Petri, B., Swanlund, N., Ho, M., Szeto, V.G., Tak, T., Koenderman, L., Pickkers, P., Tool, A.T.J., Kuijpers, T.W., van den Berg, T.K., Looney, M.R., Krummel, M.F., Kubes, P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28;2(10). pii: eaam8929. doi: 10.1126/sciimmunol.aam8929. PMID: 28626833. [PDF]

Cai, E., Marchuk, K., Beemiller, P., Beppler, C., Rubashkin, M.G., Weaver, V.M., Gérard, A., Liu, T.L., Chen, B.C., Betzig, E., Bartumeus, F., Krummel, M.F.. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118. PMID: 28495700. [PDF]

Tumeh, P.C., Hellmann, M.D., Hamid, O., Tsai, K.K., Loo, K.L., Gubens, M.A., Rosenblum, M., Harview, C.L., Taube, J.M., Handle,y N., Khurana, N., Nosrati, A., Krummel, M.F., et al. Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.Cancer Immunol Res. 2017 May;5(5):417-424. doi: 10.1158/2326-6066.CIR-16-0325. Epub 2017 Apr 14. PMID: 28411193. [PDF]

Lefrançais, E., Ortiz-Muñoz, G., Caudrillier, A., Mallavia, B., Liu, F., Sayah, D.M., Thornton, E.E., Headley, M.B., David, T., Coughlin, S.R., Krummel, M.F., Leavitt, A.D., Passegué, E., Looney, M.R. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22. PMID: 28329764. [PDF]

Wong, P.T., Roberts, E.W., Tang, S., Mukherjee, J., Cannon, J., Nip, A.J., Corbin, K., Krummel, M.F., Choi, S.K. Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer. JACS Chem Biol. 2017 Feb 17. doi: 10.1021/acschembio.6b00999. [Epub ahead of print]. PMID: 28191924. [PDF]

 

2016

Chong, S.Z., Evrard, M., Devi, S., Chen, J., Lim, J.Y., See, P., Zhang, Y., Adrover, J.M., Lee, B., Tan, L., Li, J.L., Liong, K.H., Phua, C., Balachander, A., Boey, A., Liebl, D., Tan, S.M., Chan, J.K., Balabanian, K., Harris, J.E., Bianchini, M., Weber, C., Duchene, J., Lum, J., Poidinger, M., Chen, Q., Rénia, L., Wang, C.I., Larbi, A., Randolph, G.J., Weninger, W., Looney, M.R., Krummel, M.F., Biswas, S.K., Ginhoux, F., Hidalgo, A., Bachelerie, F., Ng, L.G. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 Oct 17;213(11):2293-2314. PMCID: PMC5068243. [PDF]

Pinkard, H., Stuurman, N., Corbin, K., Vale, R., Krummel, M.F. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2016 Sep 29;13(10):807-809. doi: 10.1038/nmeth.3991. No abstract available. PMCID: PMC5100821. [PDF]

Boldajipour, B., Nelson, A., Krummel, M.F. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight. 2016 Dec 8;1(20):e89289. PMCID: PMC5135268. [PDF]

Starobinets, H., Ye, J., Broz, M., Barry, K., Goldsmith, J., Marsh, T., Rostker, F., Krummel, M., Debnath, J. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 Oct 24. pii: 85705. doi: 10.1172/JCI85705. [Epub ahead of print]. PMID: 27775547. [PDF]

Sen, D., Jones, S.M., Oswald, E.M., Pinkard, H., Corbin, K., Krummel, M.F. Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung. PLoS One. 2016 Oct 18;11(10):e0165064. doi: 10.1371/journal.pone.0165064. PMID: 27755611. [PDF]

Loyher, P.L., Rochefort, J., Baudesson de Chanville, C., Hamon, P., Lescaille, G., Bertolus, C., Guillot-Delost, M., Krummel, M., Lemoine, F.M., Combadière, C., Boissonnas, A.. CCR2 influences T regulatory cell migration to tumors and serves as a biomarker of cyclophosphamide sensitivity. Cancer Res. 2016 Sep 28. pii: canres.0984.2016. PMID: 27680685. [PDF]

Thanabalasuriar, A., Neupane, A.S., Wang, J., Krummel, M.F., Kubes, P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016 Sep 20;16(12):3260-72. doi: 10.1016/j.celrep.2016.07.052. PMID: 27653688. [PDF]

Daud, A.I., Loo, K., Pauli, M.L., Sanchez-Rodriguez, R., Sandoval, P.M., Taravati, K., Tsai, K., Nosrati, A., Nardo, L., Alvarado, M.D., Algazi, A.P., Pampaloni, M.H., Lobach, I.V., Hwang, J., Pierce, R.H., Gratz, I.K., Krummel, M.F., Rosenblum, M.D. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 Sep 1;126(9):3447-52. doi: 10.1172/JCI87324. PMCID: PMC5004965. [PDF]

Roberts, E.W., Broz, M.L., Binnewies ,M., Headley, M.B., Nelson, A.E., Wolf, D.M., Kaisho, T., Bogunovic, D., Bhardwaj, N., Krummel, M.F. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. 2016 Aug 8;30(2):324-36. doi: 10.1016/j.ccell.2016.06.003. Epub 2016 Jul 14. PMID: 27424807.[PDF]

Jones, L.M., Broz, M.L., Ranger, J.J., Ozcelik, J., Ahn, R., Zuo, D., Ursini-Siegel, J., Hallett, M.T., Krummel, M., Muller, W.J. STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis. Cancer Res. 2016 Mar 15;76(6):1416-28. doi: 10.1158/0008-5472.CAN-15-2770. Epub 2015 Dec 30. PMID: 26719528. [PDF]

Pinkard, H., Corbin, K., Krummel, M.F. Spatiotemporal Rank Filtering Improves Image Quality Compared to Frame Averaging in 2-Photon Laser Scanning Microscopy.PLoS One. 2016 Mar 3;11(3):e0150430. doi: 10.1371/journal.pone.0150430. eCollection 2016. PMCID: PMC4777388. [PDF]

Krummel, M.F., Bartumeus, F., Gérard, A. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016 Feb 8. doi: 10.1038/nri.2015.16. [Epub ahead of print]. PMID: 26852928. [PDF]

Headley, M.R., Bins, A., Nip, A., Roberts, E.W., Gerard, A., Krummel, M.F. Visualization of Immediate Immune Responses to Pioneer Metastatic Cells in the Lung. Nature. 2016 Mar 16. doi: 10.1038/nature16985. [Epub ahead of print]. PMID: 26982733. [PDF]

Mujal, A.M., Gilden, J.K., Gérard, A., Kinoshita, M., Krummel, M.F. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2016 Mar;17(3):315-22. doi: 10.1038/ni.3330. Epub 2015 Dec 21. PMCID: PMC4755847. [PDF]

 

2015

Plaks, V., Boldajipour, B., Linnemann, J.R., Nguyen, N.H., Kersten, K., Wolf, Y., Casbon, A.J., Kong, N., van den Bijgaart, R.J., Sheppard, D., Melton, A.C., Krummel, M.F., Werb, Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14;34(5):493-504. doi: 10.1016/j.devcel.2015.07.015. Epub 2015 Aug 27. PMCID: PMC4573906. [PDF]

Hashimoto, M., Yanagisawa, H., Minagawa, S., Sen, D., Ma, R., Murray, L.A., Tsui, P., Lou, J., Marks, J.D., Baron, J.L., Krummel, M.F., Nishimura, S.L. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24. PMCID: PMC4506848. [PDF]

Hashimoto, M., Yanagisawa, H., Minagawa, S., Sen, D., Goodsell, A., Ma, R., Moermans, C., McKnelly, K.J., Baron, J.L., Krummel, M.F., Nishimura, S.L. A Critical Role for Dendritic Cells in the Evolution of IL-1beta-Mediated Murine Airway Disease. J Immunol. 2015 Apr 15;194(8):3962-9. doi: 10.4049/jimmunol.1403043. Epub 2015 Mar 18. PMCID: PMC4390519. [PDF]

Broz, M.L., Krummel, M.F. The Emerging Understanding of Myeloid Cells as Partners and Targets in Tumor Rejection. Cancer Immunol Res. 2015 Apr;3(4):313-319. PMCID: PMC4391275. [PDF]

Bose, O., Baluk, P., Looney, M.R., Cheng, L.E., McDonald, D.M., Caughey, G.H., Krummel, M.F. Mast Cells Present Protrusions into Blood Vessels upon Tracheal Allergen Challenge in Mice. PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. PMCID: PMC4366375. [PDF]

Lindsay, R.S., Corbin, K., Mahne, A., Levitt, B.E., Gebert, M.J., Wigton, E.J., Bradley, B.J., Haskins, K., Jacobelli, J., Tang, Q., Krummel, M.F., Friedman, R.S. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15;194(2):522-30. doi: 10.4049/jimmunol.1400626. Epub 2014 Dec 10. PMCID: PMC4282963. [PDF]

 

2014

Mujal, A.M., Krummel, M. The subtle hands of self-reactivity in peripheral T cells. Nat Immunol. 2014 Dec 18;16(1):10-1. doi: 10.1038/ni.3060. PMID: 25521673 [PubMed - in process]. [PDF]

Broz, M.L., Binnewies, M., Boldajipour, B., Nelson, A.E., Pollock, J.L., Erle, D.J., Barczak, A., Rosenblum, M.D., Daud, A., Barber, D.L., Amigorena, S., van’t Veer, L.J., Sperling, A.I., Wolf, D.M., Krummel, M.F. 2014. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Nov 10;26, 1–15. PMCID: PMC4254577. [PDF]

Ortiz-Muñoz, G., Mallavia, B., Bins, A., Headley, M., Krummel, M.F., Looney, M.R. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Aug 20. pii: blood-2014-03-562876. [Epub ahead of print]. PMCID: PMC4208278. [PDF]

Hogan, B.L., Barkauskas, C.E., Chapman, H.A., Epstein, J.A., Jain, R., Hsia, C.C., Niklason, L., Calle, E., Le, A., Randell, S.H., Rock, J., Snitow, M., Krummel, M., Stripp, B.R., Vu, T., White, E.S., Whitsett, J.A., Morrisey, E.E. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012. PMCID: PMC4212493. [PDF]

Gérard, A., Patino-Lopez, G., Beemiller, P., Nambiar, R., Ben-Aissa, K., Liu, Y., Totah, F.J., Tyska, M.J., Shaw, S., Krummel, M.F. Detection of Rare Antigen-Presenting Cells through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g. Cell. 2014 Jul 31;158(3):492-505. DOI: 10.1016/j.cell.2014.05.044. PMCID: PMC4119593. [PDF]

Li, M., Wetzel-Strong, S.E., Hua, X., Tilley, S.L., Oswald, E., Krummel, M.F., Caron, K.M. Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice. PLoS One. 2014 Jul 10;9(7):e102356. doi: 10.1371/journal.pone.0102356. eCollection 2014. PMCID: PMC4092148. [PDF]

Lelkes, E., Headley, M.B., Thornton, E.E., Looney, M.R., Krummel, M.F. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug;35(8):379-386. doi: 10.1016/j.it.2014.05.005. Epub 2014 Jun 26. PMCID: PMC4124173. [PDF]

Corbin, K., Pinkard, H., Peck, S., Beemiller, P., Krummel, M.F. Assessing and benchmarking multiphoton microscopes for biologists. Methods Cell Biol. 2014;123:135-51. doi: 10.1016/B978-0-12-420138-5.00008-2. PMID: 24974026 [PubMed - in process]. [PDF]

Friedman, R.S., Lindsay, R.S., Lilly, J.K., Nguyen, V., Sorensen, C.M., Jacobelli, J., Krummel, M.F. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9223-8. doi: 10.1073/pnas.1322193111. Epub 2014 Jun 10. PMCID: PMC4078867. [PDF]

Patnode, M.L., Bando, J.K., Krummel, M.F., Locksley, R.M., Rosen, S.D. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30;211(7):1281-8. doi: 10.1084/jem.20132336. Epub 2014 Jun 2. PMCID: PMC4076593. [PDF]

Krummel, M.F., Friedman, R.S., Jacobelli, J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014. 30:9-16. PMID: 24905977. [PDF]

Van Dyken, S.J., Mohapatra, A., Nussbaum, J.C., Molofsky, A.B., Thornton, E.E., Ziegler, S.F., McKenzie, A.N., Krummel, M.F., Liang, H.E., Locksley, R.M. Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells. Immunity. 2014 Mar 20;40(3):414-24. doi: 10.1016/j.immuni.2014.02.003. Epub 2014 Mar 13. PMCID: PMC4019510. [PDF]

 

2013

Beemiller P., Krummel M.F. Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm. Immunol Rev. 2013 Nov;256(1):148-59. doi: 10.1111/imr.12120. PMCID: PMC3831008. [PDF]

Nussbaum, J.C., Van Dyken, S.J., von Moltke, J., Cheng, L.E., Mohapatra, A., Molofsky, A.B., Thornton, E.E., Krummel, M.F., Chawla, A., Liang, H.E., Locksley, R.M. 2013. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10;502(7470):245-248. doi: 10.1038/nature12526. Epub 2013 Sep 15. PMCID: PMC3795960. [PDF]

Jacobelli, J., Matthews, E.M., Chen, S., Krummel, M.F. 2013. Activated T Cell Trans-Endothelial Migration Relies on Myosin-IIA Contractility for Squeezing the Cell Nucleus through Endothelial Cell Barriers. PLoS One. 2013 Sep 19;8(9):e75151. doi: 10.1371/journal.pone.0075151. PMCID: PMC3777879. [PDF]

Gérard, A., Khan, O., Beemiller, P., Oswald, E., Hu, J., Matloubian, M., Krummel, M.F. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr;14(4):356-63. doi: 10.1038/ni.2547. Epub 2013 Mar 10. PMCID: PMC3962671. [PDF]

Gérard, A., Beemiller, P., Friedman, R.S., Jacobelli, J., Krummel, M.F. 2013. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan;251(1):80-96. doi: 10.1111/imr.12021. PMCID: PMC3539221. [PDF]

Cheng, L.E., Hartmann, K., Roers, A., Krummel, M.F., Locksley, R.M. 2013. Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E. Immunity. Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 Jan 3. PMCID: PMC3576928. [PDF]

 

2012

Zhang, Y., Chen, Y.C., Krummel, M.F., Rosen, S.D. 2012. Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub 2012 Sep 7. PMCID: PMC3509168. [PDF]

Beemiller, P., Jacobelli, J., Krummel, M.F. 2012. Integration of Signaling Microclusters Movement with Cellular Motility in Immunological Synapses. Nature Immunology, Nat Immunol. Jul 1. doi: 10.1038/ni.2364. PMCID: PMC3902181. [PDF].

Thornton, E.E., Krummel, M.F., Looney, M.R. 2012. Live Imaging of the Lung. Curr Protoc Cytom. Apr;Chapter 12:Unit12.28. [PDF]

Thornton, E.E., Looney M.R., Bose, O,. Sen, D., Sheppard, D., Locksley, R., Huang, X., Krummel, M.F. 2012. Spatiotemporally Separated Antigen Uptake by Alveolar Dendritic Cells and Airway Presentation to T Cells in the Lung. J Exp Med., 209(6):1183-99. PMCID: PMC3371730. [PDF]

Engelhardt, J.J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorensen, C., Werb, Z., Egeblad, M., Krummel, M.F. 2012. Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells. Cancer Cell 21, March 20; 402-417. PMCID: PMC3311997. [PDF]

Gilden, J.K., Peck, S., Chen, Y.C.M., Krummel, M.F. 2012. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. Jan 9;196(1):103-14. PMCID: PMC3255977. [PDF]

 

2011

Khan, O., Headley, M., Gerard, A., Wei, W., Liu, L., Krummel, M.F. 2011. Regulation of T Cell Priming by Lymphoid Stroma. PLoS ONE 6(11): e26138. doi:10.1371/journal.pone.0026138. PMCID: PMC3215700. [PDF]

Looney, M.R., Thornton, E.E., Sen, D., Lamm, W.J., Glenny, R.W., Krummel, M.F. 2010. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 8(1):91-6. PMCID: PMC3076005. [PDF]

 

2010

Friedman, R.S., Beemiller, P., Sorensen, C.M., Jacobelli, J., Krummel, M.F. 2010. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 11(10):953-61. PMCID: PMC2989766. [PDF]

Katzman S.D., O'Gorman W.E., Villarino A.V., Gallo E., Friedman R.S., Krummel M.F., Nolan G.P., Abbas A.K. 2010 Oct 4. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci. 107(42):18085-90. PMCID: PMC2964228. [PDF]

Beemiller, P., Krummel, M.F. 2010. Mediation of T-Cell Activation by Actin Meshworks. Cold Spring Harb Perspect Biol. 2(9):a002444. PMCID: PMC2926748.

Jacobelli, J., Friedman, R.S., Conti, M.A., Lennon-Dumenil, A.-M., Piel M., Sorensen, C.M., Adelstein, R.S., Krummel, M.F. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 11, 953-961. PMCID: PMC2943564. [PDF]

Krummel, M.F. 2010. Illuminating emergent activity in the immune system by real-time imaging. Nature Immunol. 11(7):554-7. [PDF]

Gilden J., Krummel M.F. 2010. Control of cortical rigidity by the cytoskeleton: Emerging roles for septins. Cytoskeleton (Hoboken). 67(8):477-86. PMCID: PMC2906656. [PDF]

Krummel, M.F., Cahalan, M.D. 2010. The Immunological Synapse: a Dynamic Platform for Local Signaling. J Clin Immunol. 30(3):364-72. PMCID: PMC2874029. [PDF]

Doh, J., Kim, M., Krummel, M.F. 2010. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials. Apr;31(12):3422-8. Epub 2010 Feb 1. [PDF]

Doh, J., Krummel, M.F. 2010. Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol. 340:25-50. [PDF]

 

2009

Bullen, A., Friedman, R.S., Krummel, M.F. 2009. Two-photon imaging of the immune system: A custom technology platform for high-speed, multi-color tissue imaging of immune responses. Current Topics in Microbiology and Immunology. 334: 1-29. [PDF]

Melli, K., Friedman, R.S., Finger, E.B., Miao, G. Szot, G.L., Krummel, M.F. and Tang Q. 2009. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J. Immunol. 182: 2590-600. PMCID: PMC3057894. [PDF]

Jacobelli,J., Bennett, F.C., Pandurangi, P. and Krummel, M.F. 2009. Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T cell Migration J. Immunol. 82: 2041-50. [PDF]

Fife B.T., Eagar T.N., Pauken K.E., Wu J., Obu T., Tang, Q., Azuma M., Krummel, M.F., Bluestone JA. 2009. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal. Nature Immunology. 10(11):1185-92. Epub 2009 Sep 27. PMCID: PMC2778301. [PDF]

Tooley, A.J., Gilden, J., Jacobelli, J., Trimble, W, Kinoshita, M. and Krummel, M.F. 2009. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan;11(1):17-26. doi: 10.1038/ncb1808. Epub 2008 Nov 30. PMCID: PMC3777658. [PDF]

2008

Egeblad, M.*, Ewald, A. J.*, Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. 2008. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct;1(2-3):155-67; discussion 165. doi: 10.1242/dmm.000596. Epub 2008 Sep 18. PMCID: PMC2562195. [PDF]

Mamchak, A.A., Sullivan,B.M., Hou,B., Lee,L.M., Gilden,J.K., Krummel, M.F. Locksley,R.M, DeFranco,A.L.. 2008. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J.Immunol. 181: 5374-85. PMCID: PMC2657555. [PDF]

Gardner, J.M., DeVoss. J.J., Friedman, R.S., Wong, D.J., Tan, Y.X., Johannes, K.P., Su, M.A. Chang, H.Y., Krummel, M.F., Anderson, M.S. 2008. Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells. Science. 321(5890): 843-7. PMCID: PMC2532844. [PDF]

Sabatos, C.A., Doh, J. Chakravarti, S. Friedman, R.S., Pandurangi, P.G., Tooley, A.J., Krummel, M.F. 2008. A Synaptic Basis for Paracrine Interleukin-2 Signaling in Activating T cells. Immunity. 29(3): 238-248. PMCID: PMC4466225. [PDF]

Beemiller P and Krummel MF. 2008. Distinct functions for HS1 in chemosensory versus adhesive signaling. Nat Immunol. 2008 Aug;9(8):833-4. doi: 10.1038/ni0808-833. [PDF]

Engelhardt J.J., Krummel M.F., 2008. The importance of prolonged binding to antigen-presenting cells for T cell fate decisions. Immunity. 28(2):143-5. [PDF]

 

2007

Krummel, M.F. (2007). Testing the Organization of the Immunological Synapse. Curr Opin Immunol. 19(4):460-2. PMCID: PMC2039889. [PDF]

Krummel, M.F. (2007).  Immunological Synapses: breaking up may be good to do. Cell. 129, 653-655. [PDF]

 

2006

Moldovan MC, Sabbagh L, Breton G, Sekaly RP*and Krummel MF*. (*co-last authors) 2006. Triggering of T cell activation via CD4 dimers. J Immunol. 176(9):5438-45. [PDF]

Krummel M.F. and Macara I. (2006) Maintenance and modulation of T cell polarity. Nature Immunology. 7, 1143-1149. [PDF]

Friedman, R.S. Jacobelli, J, and Krummel, M.F. (2006). Surface-bound chemokines capture and prime T cells for synapse formation. Nature Immunology 7, 1101-8. [PDF]

Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Serra, P., Santamaria, P., Krummel, M.F.* and Bluestone, J.A.* (*co-last authors) (2006). Visualizing regulatory T cell control of autoimmune response in NOD diabetic mice. Nature Immunology, 7, 83-92. PMCID: PMC3057888. [PDF]

 

2005

Friedman, R.S., Jacobelli, J., Krummel, M.F. 2005. Mechanisms of T cell Motility and Arrest: Deciphering the Relationship between Intra- and Extracellular determinants. Seminars in Immunology, 17, 387-99. [PDF]

Tooley, A.J., Jacobelli, J., Moldovan, M.C., Douglass, A., and Krummel, M.F. (2005). T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol 17, 65-75. [PDF]

Okada, T. Miller, M.J., Parker, I., Krummel, M.F., O’Garra,A. Cahalan,M.D., Cyster, J.G. (2005). Antigen-engaged B cells undergo directional migration to the T cell zone and form motile conjugates with helper T cells. PLOS Biology 3 1-13. PMCID: PMC1088276. [PDF]

 

2004

Boisvert, J., Edmondson, S. and Krummel, M.F. 2004. Immunological Synapse Formation Licenses CD40-CD40L Accumulations at T-APC Contact Sites. J. Immunol. 173, 3647-3652. [PDF]

Jacobelli, J., Andres, P.G., Boisvert, J., and Krummel, M.F. (2004). New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol 16, 345-352. [PDF]

Jacobelli, J., Chmura, S.A., Buxton, D.B., Davis, M.M., and Krummel, M.F. (2004). A single class II myosin modulates T cell motility and stopping but not synapse assembly. Nature Immunology 5, 531 - 538. [PDF]

Andres, P.G., Howland, K.C., Dresnek, D., Edmondson, S., Abbas, A.K., and Krummel, M.F. (2004). CD28 signals in the immature immunological synapse. J Immunol 172, 5880-5886. [PDF]

 

2002

Richie Ehrlich,L.I., Ebert, P.J.R. Krummel, M.F., Weiss, A. and Davis, M.M. 2002. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 17 809-822. [PDF]

Richie, L.I., P.J.R. Ebert, Wu, L.C., Krummel, M.F., Owen, J.J.T., and Davis, M.M. 2002. Imaging synapse formation during thymocyte selection: inability of CD3ζ to form a stable central accumulation during negative selection. Immunity. 16:595-606. [PDF]

Moss, W.C., Irvine, D.J., Davis, M.M., and Krummel, M.F. (2002). Quantifying signaling-induced reorientation of TCRs during immunological synapse formation. Proc Natl Acad Sci U S A 99, 15024-15029. PMCID: PMC137538. [PDF]

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